Pharmaceutical, Biotech & GMP Manufacturing worked example

Fill-Finish Throughput at 65% accepted fill yield: a worked example

Suppose accepted fill yield falls to 65%. This page works the full calculation at that level so you can see exactly which result moves and by how much. Estimate effective fill-finish throughput from filled units, run hours, and accepted fill yield.

The inputs for this scenario

  • Filled containers: 1,200 containers (held at the documented default)
  • Fill-finish run time: 8 hr (held at the documented default)
  • Accepted fill yield: 65 % (the input this scenario stresses; the baseline uses 90)

Working through the calculation

  • The calculation starts from the formula this tool documents: Gross throughput = Filled containers รท Fill-finish run time.
  • Effective throughput works out to 97.5 units/hr at these inputs, and this is the headline figure for the scenario.
  • Raw throughput works out to 150 units/hr at these inputs.
  • Efficiency works out to 65 % at these inputs.
  • Runtime works out to 8 hr at these inputs.

How this compares with the baseline

  • Against the tool's baseline example, where accepted fill yield sits at 90% and the headline result is 135 units/hr, this scenario comes in 27.78% below the baseline at 97.5 units/hr.
  • It computes gross throughput in units per hour and effective throughput after applying accepted fill yield. When the numbers land here, the stressed input is the lever to work; the walkthrough above shows exactly how much each output recovers as it climbs back toward the baseline.

Results at a glance

  • Effective throughput: 97.5 units/hr (headline result)
  • Raw throughput: 150 units/hr
  • Efficiency: 65 %
  • Runtime: 8 hr

Run it with your numbers

  • To rerun this with your own numbers, open the live Fill-Finish Throughput calculator, set accepted fill yield to your actual value, and adjust the remaining inputs to match your operation.

Last reviewed 2026-05-12.